Due to an unfortunate accident involving Obelix throwing a menhir, Getafix the druid not only loses his memory, but goes completely mad. Now deprived of the wisdom of their beloved druid and the protection provided by his magic potion, the Armorican village falls prey to a proclaimed soothsayer who comes with ominous predictions and overweening ambitions. It's up to Asterix to keep his villager friends within reason and hopefully get Getafix to remember the magic potion's recipe before the impending Roman attack.
Life in Solby is nice and peaceful until one day Mitcho and Sebastian find a message in a bottle by the harbour. The bottle is from the missing mayor of Solby with a message that he is on a mysterious island and has made a great discovery. Now they must embark on a perilous journey to help save the mayor and bring him home, and in the process they uncover something that will bring great pleasure to the city of Solby – a giant pear.
Set in the neurosurgical ward of Copenhagen's Rigshospitalet, the city and country's main hospital, nicknamed "Riget", a number of characters, staff and patients alike, encounter bizarre phenomena, both human and supernatural.