Years after a series of random murders took place in 2017, book author Michael Lane suddenly begins receiving haunting calls from the unknown. Instead of focusing on the encore to his successful debut book, he becomes obsessed with this mystery and spirals out of control as he unravels each victim caught in the web of a sadistic killer.
The film follows the story of Jamie, a struggling butch lesbian actress who gets cast as a man in a film. The main plot is a romantic comedy between Jamie's male alter-ego, "Male Jamie," and Jill, a heterosexual woman on set. The film's subplots include Jamie's bisexual roommate Lola and her cat actor Howard, Lola's abrasive butch German girlfriend Andi, and Jamie's gay Asian friend David.
