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Kickboxing champion Matt Reeves witnesses the murder of his friend Johnny. While investigating the crime, he learns that a Mr. Negaal in South Africa has founded a new kickboxing association and does not leave international champions much of a chance. Johnny had to pay with his life when he did not want to join. Neegal seems to kill everybody who is in his way especially David Sloan from the previous Kickboxer films. Matt is on his own now, but suddenly finds an unexpected ally.
An author who was sent to the town Drakho, because of a nervous breakdown, gets wound up in a mystery revolving around demons and werewolves. She starts seeing ghosts and dismisses them as her own imagination, but when they turn out to be real she becomes suspicious of the odd town and of its past.
A Russian KGB agent is sent to Africa to kill an anti-Communist black revolutionary. However, he has a change of heart when he sees how the Russians and their Cuban allies are killing and repressing the locals, so he switches sides and helps the rebels.
A rowdy rock group are accompanied by a film crew to desolate Lake Infinity to produce a music video. One night the musicians visit the local pub while the various members of the film crew satisfy their carnal desires with one another aboard the luxurious houseboat they are all staying in. They are so busy they fail to notice that a rampaging lunatic has snuck aboard the boat, and one by one the various characters are brutally slaughtered in a variety of grisly ways.
