When a lively young family moves in next door, grumpy widower Otto Anderson meets his match in a quick-witted, pregnant woman named Marisol, leading to an unlikely friendship that turns his world upside down.
A financial adviser drags his family from Chicago to the Missouri Ozarks, where he must launder $500 million in five years to appease a drug boss.
In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.