Two mental patients with opposite personalities ditch their Tuscan hospital and embark on an unpredictable exploration of the real world.
While visiting Universal Studios in Hollywood along with their respective families, two Italian tourists get on a real time machine and got lost in time. Professor Mortimer effort to rescue them result in trips through various ages of ancient Italy.
Jacopo, Duccio, Cecco, Manfredo and Filippo are five friends who live in Florence of the fifteenth century, during a plague epidemic.