Ex-special operative MacGruber is called back into action to take down his archenemy, Dieter Von Cunth, who's in possession of a nuclear warhead and bent on destroying Washington, DC.
It is 1879 in the Dakota Territories, a band of men who set out to find and recover a family of settlers that has mysteriously vanished from their home. Expecting the offenders to be a band of fierce natives, but they soon discover that the real enemy stalks them from below.