When shark conservationist Dr. Misty Calhoun is invited to consult on a top-secret project run by pharmaceutical billionaire Carl Durant, she is shocked to learn that the company is using unpredictable and highly aggressive bull sharks as its test subjects, which soon break loose and cause havoc.
A father survives a plane crash in rural Appalachia, but becomes suspicious of the elderly couple who take him in to nurse him back to health with the ancient remedies.
