A young Sicilian is swindled twice, but ends up rich; a man poses as a deaf-mute in a convent of curious nuns; a woman must hide her lover when her husband comes home early; a scoundrel fools a priest on his deathbed; three brothers take revenge on their sister's lover; a young girl sleeps on the roof to meet her boyfriend at night; a group of painters wait for inspiration; a crafty priest attempts to seduce his friend's wife; and two friends make a pact to find out what happens after death.
History Professor Brad Fletcher heads west for his health, but falls in with Soloman Bennett's outlaw gang. Fascinated by their way of life, Fletcher finally takes over the gang, leading with a new 'efficient' ruthlessness.
After a stagecoach is robbed and the passengers murdered, a long and tangled series of surprise attacks and murderous double-crosses, leaves the coach's strongbox in the hands of the killer Lasky. It is up to the legendary hero Sartana to track down the missing money and determine just who is ultimately behind the grisly robberies and killings.