A few decades after the destruction of the Inca Empire, a Spanish expedition led by the infamous Aguirre leaves the mountains of Peru and goes down the Amazon River in search of the lost city of El Dorado. When great difficulties arise, Aguirre’s men start to wonder whether their quest will lead them to prosperity or certain death.
Fred Engel's father is murdered by Colonel Brinkley in order to acquire a treasure map, however the Colonel only acquires half of it, the other half as held by Mrs. Butler. Discovering the scene of the crime, Old Shatterhand and Winnetou help Fred bring his father's murderer to justice and locate the treasure of Silver Lake.
The sister of a famous, but as yet uncaught, criminal named "The Hexer" is murdered. Inspector Higgins of Scotland Yard believes that "The Hexer" will surface to take his revenge on his sister's killers, and plans to set a trap to finally capture him. However, soon bodies start piling up, and it looks as if "The Hexer" may get away yet again.
