The Newton family live in their comfortable home, but there seems to something missing. This "hole" is filled by a small puppy, who walks into their home and their lives. Beethoven, as he is named, grows into a giant of a dog... a St Bernard. Doctor Varnick, the local vet has a secret and horrible sideline, which requires lots of dogs for experiments. Beethoven is on the bad doctor's list.
Clue finds six colorful dinner guests gathered at the mansion of their host, Mr. Boddy -- who turns up dead after his secret is exposed: He was blackmailing all of them. With the killer among them, the guests and Boddy's chatty butler must suss out the culprit before the body count rises.
A disgruntled ex-CIA operative, his assistant and their assembled group of terrorists seize a battleship with nuclear blackmail in mind. They've planned for every contingency but ignore the ship's cook, former Navy SEAL Casey Ryback—an error that could be fatal.
