Seethamma Vakitlo Sirimalle Chettu revolves around a lovable family headed by Relangi . He has two sons- Vijay "Peddodu" and Ajay "Chinnodu". The unemployment of his children and the ridicule heaped on the family by relatives puts some strain on the relationships. What does he do in these circumstances is the rest of the story.
A crime-lord frames Raghuram, an innocent man, to hide his misdeeds. However, an undercover policeman, Vamsi, sets out to catch Raghuram but realises that he is not the culprit.
When her joint family breaks apart, daughter-in-law Uma solves everyone's problems and unites the family again.
