Ninagawa is a powerful man in Japanese politics and with top economic connections.His granddaughter is then murdered. The suspect is Kunihide Kiyomaru. Kunihide Kiyomaru has a prior conviction for assaulting and killing a girl 8 years ago. The police could never apprehend the suspect in the prior killing.
In the fourth film of the Lone Wolf and Cub series, Ogami Itto is hired to kill a tattooed female assassin and battles Retsudo, head of the Yagyu clan, and his son Gunbei.
In the third film of the Lone Wolf and Cub series, Ogami Itto volunteers to be tortured by Yakuza to save a prostitute and is hired by their leader to kill an evil chamberlain.