A dangerous combination of radiation and insecticide causes the unfortunate Scott Carey to shrink, slowly but surely, until he is only a few inches tall. His home becomes a wilderness where he must survive everything from spiders living in the cellar to his beloved cat.
Baggage handlers Bud and Lou accidentally stumble upon Frankenstein's Monster, Dracula and the Wolf Man.
Navy Commander Alan Roberts is assigned to lead an expedition to Little America in Antarctica to investigate reports of a mysterious warm water inland lake discovered a decade earlier. His helicopter and its small party, including reporter Maggie Hathaway, is forced down into a volcanic crater by a fierce storm. They find themselves trapped in a lush tropical environment that has survived from prehistoric times.
