Bruno Fioretti, known as "Mandrake", is an inveterate gambler who never misses a day at the horse racing track in Rome. He is doubly unlucky: he bets too much on one horse, and his wife is sleeping with his best friend because Mandrake is always at the track. Penniless and cuckolded, Mandrake decides to make one last bet.
Bill Meceita, a boy whose family was murdered in front of him by a gang, sets out 15 years later to exact revenge. On his journey, he finds himself continually sparring and occasionally cooperating with Ryan, a gunfighter on his own quest for vengeance, who knows more than he says about Bill's tragedy.
Two young women, Margaret and Lisa, are set to take the overnight train from Munich in Germany to stay with Lisa's parents in Italy for Christmas. Unfortunately a pair of psychotic hoodlums and an equally demented nymphomaniac woman terrorize the pair.
