Country doctor Jack Jackson is called in to treat the Sick-Little-Well-Girl, who has been making Dr. Saulsbourg and his sanitarium very rich after years of unsuccessful treatment.
A healthy outdoors-type follows the girl he loves to a resort for wealthy hypochondriacs. In order to prove to her and the other patients that their "illnesses" are all in their minds, he hatches a scheme to take them on a boat ride, then get them stranded in the wilderness, where he can show them that they can live without their pills, doctors and "cures".
Ole Olsen and Chic Johnson are Broadway stars who return to Universal Studios to make another movie. The mere mention of Olsen and Johnson's names evacuates the studio and terrorizes the management and personnel. Undaunted, the comedians hire an assistant director and unknown talent, and set out to make their own movie.
