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Years after Barry Thornton disappears from Panama while under suspicion of stealing American defense plans for the canal, his daughter Eleanor, now the ward of Barry's twin brother Dana, is still obsessed with the mystery. Senator Carew informs her that he has solved it, but he is murdered before he can give her the details.
Sick of life in the city after his fiancée deserts him, Merrill Day goes to the country for a rest with his sister and niece. There he meets Joan, who has lived in the hills for her whole life, and they quickly begin a romance. Grekko, however, a hunchback who has loved Joan for years, convinces her that Merrill's sister is really Merrill's wife.
Cardelanche, the son of an Indian chief, returns from the East to find himself rejected by his own people. He is made captain of the U.S. army when he saves a detachment of cavalry from a group of renegade Indians, and further removes himself from his race when he develops a relationship with Miriam, the daughter of the Fort Remmington commandant. Lieutenant Parkman (Walker) gets into a fight with Cardelanche when Parkman is demoted, while General Custer's troops are slaughtered by Cardelanche's people. Cardelanche decides that his true allegiance is to his own race, and gives up Miriam to return to them.
Things appear to be looking up for a cash-strapped, regional hospital when it hires a reputedly brilliant cardiac surgeon to head up its pediatric cardiac surgery unit. But when increasing numbers of children begin dying on the operating table, the unit's top O.R. nurse begins to suspect that the new surgeon is not as experienced as everyone has been lead to believe. She finds herself alone, faced with jeopardizing the career she loves by taking on the powers that be and blowing the whistle on the influential surgeon and the harrowing goings-on at the hospital.
