The story of New Jersey-based Italian-American mobster Tony Soprano and the difficulties he faces as he tries to balance the conflicting requirements of his home life and the criminal organization he heads. Those difficulties are often highlighted through his ongoing professional relationship with psychiatrist Jennifer Melfi. The show features Tony's family members and Mafia associates in prominent roles and story arcs, most notably his wife Carmela and his cousin and protégé Christopher Moltisanti.
Looking at the lives of former and current football players, the show follows former superstar Spencer Strasmore as he gets his life on track in retirement while mentoring other current and former players through the daily grind of the business of football.
On a special inner city street, the inhabitants—human and muppet—teach preschoolers basic educational and social concepts using comedy, cartoons, games, and songs.