After facing defeat at the hands of Cristaldi the magician, Dracula is back to seek revenge and rule the world. With the help of Wolfman and his legion of followers, victory seems eminent. Professor Cristaldi, a descendant of the magician, is warned about Dracula's plans and calls upon El Santo and Blue Demon in the hopes that they can put the infamous Count and the werewolf down for good.
Innocent women are being kidnapped and used as guinea pigs for a brain transplant experiment. The diabolical Dr. Frankenstein continues his quest to perfect his brain transplant operation to bring back his deceased wife at any cost - even if it means playing with the lives of others. El Santo and Blue Demon are called in to help when their friend Alicia becomes Dr. Frankenstein's next target. It'll take both heroes to go up against the dastardly doctor and go mano a mano with his super strong zombie Golem.
Dr. Frankenstein and her assistant, Dr. Yanco, are going to bring one of their experiments to life in Santo Vs. Frankenstein's Daughter. She intends to use a monster named Ursus to do her evil bidding. Using a youth serum to retain their vitality, the doctors set their sights upon none other than El Santo. They need his super human blood to regenerate a stronger youth serum. They kidnap Santo's goddaughter, Norma and lure him into Dr. Frankenstein's lab where he is captured and enslaved. Will Santo make it out alive?
