After experimenting on himself and becoming invisible, scientist Jack Griffin, now aggressive due to the drug's effects, seeks a way to reverse the experiment at any cost.
A runaway heiress makes a deal with the rogue reporter trailing her but the mismatched pair end up stuck with each other when their bus leaves them behind.
After the death of a United States Senator, idealistic Jefferson Smith is appointed as his replacement in Washington. Soon, the naive and earnest new senator has to battle political corruption.
