The film demonstrates all stages of production of the yellow fever vaccine that took place in the Yellow Fever Service laboratory of the Rockefeller Foundation, located in Manguinhos, Rio de Janeiro, next to the Oswaldo Cruz Institute.
At the Rockefeller Foundation, the rat colony for experiments with viruses and antibodies in humans. In Ilha dos Macacos, next to the Oswaldo Cruz Institute, in Rio de Janeiro, the creation of Rhesus monkey by the Rockefeller Foundation - a primate species that allows the monitoring of experimental yellow fever.
Carlos Sebastião Prata Filho watches, for the first time, an interview given in 1963 by his father: Grande Othello. Alongside his four children, Grande Othello talks about his first experience in theater. Roquete Pinto, the interviewer, then starts asking the boys questions and records unexpected moments.
