Everyone has 'moved on', except for Sherman and Jim Levenstein's still understanding father. Little Matt Stiffler wants to join his older brother Steve's business and, after everything Matt has heard from Jim's band-geek wife, he plans to go back to band camp and make a video of his own.
When Erik Stifler realizes that he's the only Stifler family member who might graduate high school a virgin, he decides to live up to his legacy. After some well-meaning advice from Jim's dad, Erik's ready to take his chances at the annual and infamous Naked Mile race, where his devoted friends and some uninhibited sorority girls will create the most outrageous weekend ever.
College freshman Sydney White arrives at Southern Atlantic University, determined to pledge her late mother's sorority. Unfortunately, she finds that the sisterhood has changed since her parent's day. Banished to a condemned house, Sydney joins forces with seven outcasts to take over the student government and win equal rights for nerd and noted alike.
