In the year 2035, convict James Cole reluctantly volunteers to be sent back in time to discover the origin of a deadly virus that wiped out nearly all of the earth's population and forced the survivors into underground communities. But when Cole is mistakenly sent to 1990 instead of 1996, he's arrested and locked up in a mental hospital. There he meets psychiatrist Dr. Kathryn Railly and the son of a famous virus expert who may hold the key to the Army of the 12 Monkeys; thought to be responsible for unleashing the killer disease.
After his long-time girlfriend dumps him, a thirty-year-old record store owner seeks to understand why he is unlucky in love while recounting his "top five breakups of all time".
British Ministry agent John Steed, under direction from "Mother", investigates a diabolical plot by arch-villain Sir August de Wynter to rule the world with his weather control machine. Steed investigates the beautiful Doctor Mrs. Emma Peel, the only suspect, but simultaneously falls for her and joins forces with her to combat Sir August.
