The life of an unsuccessful writer is transformed by a top-secret 'smart drug' that allows him to use 100% of his brain and become a perfect version of himself. His enhanced abilities soon attract shadowy forces that threaten his new life.
Summoned from an ashram in Tibet, Ace finds himself on a perilous journey into the jungles of Africa to find Shikaka, the missing sacred animal of the friendly Wachati tribe. He must accomplish this before the wedding of the Wachati's Princess to the prince of the warrior Wachootoos. If Ace fails, the result will be a vicious tribal war.
Manhattan drag queens Vida Boheme and Noxeema Jackson impress regional judges in competition, securing berths in the Nationals in Los Angeles. When the two meet pathetic drag novice Chi-Chi Rodriguez — one of the losers that evening — the charmed Vida and Noxeema agree to take the hopeless youngster under their joined wing. Soon the three set off on a madcap road trip across America and struggle to make it to Los Angeles in time.
