On their cross-country drive, a married couple, Jeff and Amy Taylor, experience car trouble after their SUV breaks down. Stranded in the New Mexico desert, the two catch a break when a passing truck driver offers Amy a ride to a nearby café to call for help. Meanwhile, Jeff is able to fix the car and make his way to the café, but Amy isn't there. He tracks down the trucker -- who tells the police he's never seen Jeff or his wife before. Jeff then begins a desperate, frenzied search for Amy.
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Dr. Eric Vornoff, with the help of his mute assistant Lobo, captures twelve men for a grisly experiment; His goal to turn them into supermen using atomic energy. Reporter Janet Lawton, fiancée of the local lieutenant, vows to investigate Vornoff's supposedly haunted house.
Don Gregor, the son of famous plastic surgeon Dr. Boris Gregor, begins to hang around with young criminal Vic Brady and carry a gun. The pair attempt an armed holdup, and when things start to go wrong Gregor accidentally kills a night watchman. Fearing that Gregor plans to turn himself in, Brady kills him and blackmails Dr. Gregor into giving him a new face.
A scientist and a gang that has kidnapped a rich heiress come up against a beautiful but lethal alien who has crash-landed her spaceship on Earth.
