Picking up directly where the previous film left off, the story follows Riley, one of the last people to come in contact with Samantha, as he scrambles to track down those responsible for the outbreak before the highly contagious disease not only consumes his body, but the world as we know it.
Jake Carter and another former Marine, Luke Trapper, join forces to rescue a young kidnapped girl from a gang of international criminals.
After being whisked away to Los Angeles by a handsome Hollywood star, Katie is left alone in his apartment, where strange and scary things begin to happen.
