Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.
A small town is suddenly and inexplicably sealed off from the rest of the world by an enormous transparent dome. While military forces, the government and the media positioned outside of this surrounding barrier attempt to break it down, a small group of people inside attempt to figure out what the dome is, where it came from, and when (and if) it will go away.
After Portland homicide detective Nick Burkhardt discovers he's descended from an elite line of criminal profilers known as "Grimms," he increasingly finds his responsibilities as a detective at odds with his new responsibilities as a Grimm.
