William Blake, an accountant turned fugitive, is on the run. During his travels, he meets a Native American man called Nobody, who guides him on a journey to the spiritual world.
A farm boy reluctantly becomes a member of the undead when a girl he meets turns out to be part of a band of vampires who roam the highways in stolen cars.
In Memphis, Tennessee, over the course of a single night, the Arcade Hotel, run by an eccentric night clerk and a clueless bellboy, is visited by a young Japanese couple traveling in search of the roots of rock; an Italian woman in mourning who stumbles upon a fleeing charlatan girl; and a comical trio of accidental thieves looking for a place to hide.
