A robotics company vying to win a lucrative military contract team up with a corrupt CIA agent to conduct an illegal live field test. They deploy four weaponized prototype robots into a suspected drug manufacturing camp in the Golden Triangle, assuming they'd be killing drug runners that no one would miss. Six doctors on a humanitarian mission witness the brutal slaughter and become prime targets.
As the streets of Los Angeles overflow with camera-wielding gawkers seeking to capture images of a bizarre police pursuit, the same people who sought to exploit the suffering of others for amusement on the Internet become the stars of a gruesome viral video from which no one gets out alive.
Steve McGarrett returns home to Oahu, in order to find his father's killer. The governor offers him the chance to run his own task force (Five-0). Steve's team is joined by Chin Ho Kelly, Danny "Danno" Williams, and Kono Kalakaua.
