Roy and Gilbert's fishing trip takes a terrifying turn when the hitchhiker they pick up turns out to be a sociopath on the run from the law. He's killed before, and he lets the two know that as soon as they're no longer useful, he'll kill again. The two friends plot an escape, but the hitchhiker's peculiar physical affliction, an eye that never closes even when he sleeps, makes it impossible for them to tell when they can make a break for it.
San Francisco businessman Harry Graham and his wife and business partner, Eve, are in the process of adopting a child. When private investigator Mr. Jordan uncovers the fact that Graham has another wife, Phyllis, and a small child in Los Angeles, he confesses everything.
When an assassin's bullet confines him to a wheelchair for life ending his career as Chief of Detectives, Robert T. Ironside becomes a consultant to the police department. Detective Sergeant Ed Brown and policewoman Eve Whitfield join with him to crack varied and fascinating cases. Ex-con Mark Sanger is employed by the chief as home help but eventually becomes a fully fledged member of the team also. Officer Whitfield leaves after 4 years service, and is replaced by Officer Fran Belding.
