Celestine gets hooked on a new dangerous drug, Nepenthe, and is visited by a mysterious woman named Irene who subtly pushes her towards madness. Meanwhile, Bob and his friends try to save Celestine from her newfound insanity.
Hit by the realization that his hustle is taking him nowhere, Johnny is on the verge of giving up boxing when nurse Ava gives him a much-needed nudge into trying again.
