David Cuevas is a family man who works as a gangland tax collector for high ranking Los Angeles gang members. He makes collections across the city with his partner Creeper making sure people pay up or will see retaliation. An old threat returns to Los Angeles that puts everything David loves in harm’s way.
Steve McGarrett returns home to Oahu, in order to find his father's killer. The governor offers him the chance to run his own task force (Five-0). Steve's team is joined by Chin Ho Kelly, Danny "Danno" Williams, and Kono Kalakaua.
Two contract killers are hired by competing cartels to hunt down an elusive drug scientist. The scientist escapes, leading to a globetrotting chase and fight for survival.