Returning to the same medical school where they were test subjects years before, two twisted serial killers use brutal sex acts to kill off a group of med students.
A group of friends get lost in the seedy streets where they encounter a crazed gang of homeless derelicts that seizes them and kills them one by one. The surviving man escapes on foot, naked and unarmed, with a pack of depraved transients in pursuit, and only seconds away from capture.
