Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.
Two artistically inclined childhood friends, a comedian and a folk-rocker respectively, set out on a tour together in hopes of regaining their "mojo" and finding love in the process.
Ten-year-old Nico struggles to understand his parents break-up until memories of a fateful sleepover resurface, revealing a clue.