A man named Seligman finds a fainted wounded woman in an alley and he brings her home. She tells him that her name is Joe and that she is nymphomaniac. Joe tells her life and sexual experiences with hundreds of men since she was a young teenager while Seligman tells about his hobbies, such as fly fishing, reading about Fibonacci numbers or listening to organ music.
Metal drummer Ruben begins to lose his hearing. When a doctor tells him his condition will worsen, he thinks his career and life is over. His girlfriend Lou checks the former addict into a rehab for the deaf hoping it will prevent a relapse and help him adapt to his new life. After being welcomed and accepted just as he is, Ruben must choose between his new normal and the life he once knew.
Minnie Goetze is a 15-year-old aspiring comic-book artist, coming of age in the haze of the 1970s in San Francisco. Insatiably curious about the world around her, Minnie is a pretty typical teenage girl. Oh, except that she’s sleeping with her mother’s boyfriend.
