A bank-robbing gang of misfits heads to Mexico with the blueprints for the perfect million-dollar heist, but when one of the crooks wanders into the wrong bar, the thieving cohorts develop a thirst for blood.
Brothers John and Matt have inherited an island cabin from their recently deceased uncle. Along with Matt's girlfriend, Nicki, and other mutual friends, the siblings travel to the cabin for a relaxing weekend getaway. But, not long after arriving, the group is besieged by ravenous dogs. They watch in horror as another vacationer, Luke, is eaten alive. Soon, they discover a training facility where the dogs have been bred to kill.
Narrowly escaping death, outlaw Johnny Madrid goes on the run with the hangman's sensuous daughter Esmeralda by his side.
