A father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.
Three friends begin a dangerous three-way relationship that spirals out of control, leading to dire consequences that haunt them ten years later.