Frankenstein's unscrupulous colleague, Dr. Bohmer, plans to transplant Ygor's brain so he can rule the world using the monster's body, but the plan goes sour when he turns malevolent and goes on a rampage.
Aircraft factory worker Barry Kane flees across the United States after he is wrongly accused of starting the fire that killed his best friend.
In San Francisco, detective partners Jack Packard and Doc Long are hired by socialite Jefferson Monk who believes someone is following him with the aim to kill him.