Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.
Two leading computer scientists work toward their goal of Technological Singularity, as a radical anti-technology organization fights to prevent them from creating a world where computers can transcend the abilities of the human brain.
Blade forms an uneasy alliance with the vampire council in order to combat the Reapers, who are feeding on vampires.