When a Spanish Jesuit goes into the South American wilderness to build a mission in the hope of converting the Indians of the region, a slave hunter is converted and joins his mission. When Spain sells the colony to Portugal, they are forced to defend all they have built against the Portuguese aggressors.
In the fascist Italy of 1935, a painter trained as a doctor is exiled to a remote region near Eboli. Over time, he learns to appreciate the beauty and wisdom of the peasants, and to overcome his isolation.
Renzo falls in love with feminist Margherita, too emancipated for him: they start a troubled relationship until he kidnaps her, forcing her to be an housewife devoted to her husband.