In New York City, detective Luigi Mackeroni investigates a string of mysterious penile mutilations at the Hotel Quickie. After Mackeroni attempts to have a tryst with a gigolo he meets in the lobby, a carniverous condom bites off his right testicle and flees, which sets the detective off on a quest to stop the predatory prophylactic once and for all.
Martin is the ambitious one in the family. He is poised to start on his doctorate, when he is diagnosed with testicular cancer and all his future plans begin to unravel. The removal of one testicle reduces the most immediate threat, but the cancer has already spread and Martin's doctor argues for an operation that would save him, but could also castrate him.
Adult dreamer Tristan still lives under his mother's thumb. After she has a health scare, he realizes how much he wants her gone... permanently.
