The gang creates their own railroad after being chased from a local railyard, and competes with Toughie.
Mickey Daniels doing an impersonation of Sherlock Holmes and Joe Cobb being Watson as the two try to discover the whereabouts of a young rich kids who has gone missing. While trying to find the kid the gang must also try and avoid a dumb detective also working the case.
The gang operates a donkey-propelled tour bus. Later, a cut-rate vaudeville producer hires them to help out with his show, which they wreck.
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An emotionally scarred highway drifter shoots a sadistic trick who rapes her, and ultimately becomes America's first female serial killer.