Isolated bell-ringer Quasimodo wishes to leave Notre Dame tower against the wishes of Judge Claude Frollo, his stern guardian and Paris' strait-laced Minister of Justice. His first venture to the outside world finds him Esmeralda, a kind-hearted and fearless Romani woman who openly stands up to Frollo's tyranny.
Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.
Two strangers are drawn to a mysterious pharmaceutical trial that will, they're assured, with no complications or side-effects whatsoever, solve all of their problems, permanently. Things do not go as planned.