Like most of the people in her town, Karen Silkwood works at the local nuclear plant producing highly radioactive plutonium. Exposed one day to a lethal dose of radiation, Karen faces the blank walls of corporate indifference and denial. As her illness increases, her protest grows louder and she becomes an obvious danger to the powers that be.
A New York schoolteacher hits a midlife crisis when, in quick succession, her husband leaves, her adoptive mother dies and her biological mother, an eccentric talk show host, materializes and turns her life upside down as she begins a courtship with the father of one of her students.
A newspaper photographer researches an 1873 double homicide and finds her own life paralleling that of a witness who survived the tragic ordeal.
