In a prologue and four acts (the prologue and the first act are lost so is necessary to describe what happens with title cards) the film depicts the terrible dream of Asmus wherein the devil joins the human world disguised as a tinker. He meets Frau Ane, Asmus' wife; Ane yearns to have a baby but in vain so the devil takes advantage of Frau Ane's motherly inner desire by making a deal with her but for his own purposes. As a result, the farmer's wife comes under the devil's spell and then seduces the local priest, giving the devil to chance to build his own church to replace the old church that has burned down.
A scientist, Professor Jakob ten Brinken, interested in the laws of heredity, impregnates a prostitute in a laboratory with the semen of a hanged murderer. The prostitute conceives a female child who has no concept of love, whom the professor adopts. The girl, Alraune, suffers from obsessive sexuality and perverse relationships throughout her life. She learns of her unnatural origins and she avenges herself against the professor.
