A group of teens break into a blind man's home thinking they'll get away with the perfect crime. They're wrong.
Vampires and werewolves have waged a nocturnal war against each other for centuries. But all bets are off when a female vampire warrior named Selene, who's famous for her strength and werewolf-hunting prowess, becomes smitten with a peace-loving male werewolf, Michael, who wants to end the war.
In the dark heart of a sprawling, anonymous city, two assassins carry out a sinister mission, a teacher battles a fatal illness, and an enigmatic janitor and a curious waitress lead dangerous double lives. Murderous consequences unravel in the dead of night, as their lives intertwine at the hands of a mysterious criminal mastermind who is hell-bent on revenge.
